JWH-250, also known as (1-pentyl-3-(2-methoxyphenylacetyl)indole), is a phenylacetylindole analgesic that acts as a cannabinoid agonist at both the CB1 and CB2 receptors, with a Ki of 11 nM at CB1 and 33 nM at CB2. JWH-250 has no therapeutic use, but it is found in many herbal products that are smoked for their psychoactive effects.

JWH-250 and JWH-073 are cannabinoid agonists with nanomolar affinity for CB1 and CB2 receptors, respectively. They are illegally marketed as “herbal blends” for producing psychoactive effects greater than Cannabis. We recently examined a “herbal” preparation containing both JWH-250 and JWH-073.

JWH-250 (2-(2-Methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone)

JWH-018 is intentionally spiked on plant material and has no known legitimate use outside of research. It has been found in a variety of herbal incense products, including “Spice,” “K2,” and other similar products smoked for their psychoactive effects.
In the United States, JWH 250 is classified as a Schedule I compound. This product is intended for forensic and research purposes.
Naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) is a psychoactive “spice” compound that activates cannabinoid receptors.

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